Socially housing male CD-1® mice in a laboratory environment: A two-phase study

National AALAS 2024 -- Male mice live socially together in the wild. Typically, in groups of one sexually mature male and multiple females. Due to animal welfare concerns, some facilities moved toward single housing of males. Laboratories have success when submissive males have space to escape aggressor, and the cage has adequate resources to mitigate resource guarding. The goal of this study was to find a solution to socially house male mice while making minimal adjustments to current facility housing standards.

Novel approaches to social housing and enrichment to improve welfare for rabbits, rats, guinea pigs and mice

National AALAS 2024 -- Over the past year, our team has been working on ways to provide additional social and environmental enrichment, and we have introduced pool parties to our rabbits, guinea pigs and rats. During this time, we also started housing our mice in larger, rat polycarbonates cages, giving them double the space that they were used to. We also added more enrichment for the rabbits and guinea pigs, such as loose hay stuffed in toys and frozen fruit treats. Overall, we saw many positive changes in the animals, their environments and the way they interacted with staff.

A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors

Estrous evaluation in Sprague Dawley® and Wistar Han® rats: Morning vs. afternoon comparison

National AALAS 2024 -- Determination of the phases of estrous cycle in experimental rat studies is important for reproductive function studies and is required by different regulatory authorities. Vaginal smears are usually collected in the morning (e.g., between 08:00 to 12:00 at our facility). However, sample collections in the early morning could lead to missed proestrus stage and could be challenging when multiple studies are conducted at the same time in the same test facility. To minimize missed proestrus stage and to provide timing flexibility of sample collection, we evaluated the vaginal smear samples collected in the morning and afternoon in Sprague Dawley® and Wistar Han® rats.

Labcorp Announces Availability of First Companion Diagnostic Assay to Identify Gastric Cancer Patients Eligible for Targeted Treatment with VYLOY™

BURLINGTON, N.C. (October 31, 2024) – Labcorp (NYSE: LH), a global leader of innovative and comprehensive laboratory services, today announced its readiness to begin providing the Roche VENTANA® CLDN18 (43-14A) RxDx Assay in the United States. 

Transgenic Rodent Assay Muta™Mouse (OECD 488)

The transgenic rodent (TGR) assay is a powerful tool to assess the mutagenic potential of a compound in vivo.

Empowering patients with breast cancer to talk to their oncologist about HER2 status

Unlocking the future of antibody-drug conjugates

Labcorp bioanalytical services has supported nearly half of the approved antibody - drug conjugates (ADCs) on market today. Access the on-demand session as we discuss LBA and LC-MS insights gleaned from our deep bioanalytical experience with ADCs, bioanalytical opportunities and challenges we have encountered, how innovative strategies can overcome key issues, and a forward-looking perspective on ADC bioanalytical strategies for this rapidly evolving market.

Labcorp Announces 2024 Third Quarter Results

Updates Full-Year Guidance Results from Continuing Operations for third quarter 2024 versus last year: Revenue: $3.28 billion versus $3.06 billion Diluted EPS: $2.00 versus $2.11 Adjusted EPS: $3.50 versus $3.38 Free Cash Flow: $162 million versus $171 million Updated Full-Year 2024 Guidance: