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July 18, 2019

The path to PV automation: Past, present and future

Explore the current state of PV automation in light of the challenges being faced by the industry and the PV automation landscape, as well as Covance's recent innovations in automation and the how these solutions have benefited our sponsors.

July 19, 2019

Creating Value - Compressing Time - Refining Burn Rate Forecasts: The Molecule Development Team (MDT)

Product development in health sciences is complex and costly. It can take many years to gain marketing approval for a new drug, device or diagnostic. And while there are many potential potholes along the development highway, there are also numerous opportunities to accelerate development and create benefits for all stakeholders.

July 28, 2019

Validation of UGT Inhibition Assays for DDI Assessment

ISSX 2019 -- Potential drug-drug interactions (DDI) mediated by inhibition of uridine di-phospho-glucuronosyltransferase (UGT) enzymes are of increasing focus.

August 4, 2019

NarlaAACC19-FCAL.pdf

AACC 2019 -- Calprotectin is a calcium-heterodimer protein which is abundant in the cytoplasm of neutrophils. This is a biomarker with good sensitivity and specificity in case of inflammatory Bowel disease (IBD) which is a chronic inflammatory gut.

August 4, 2019

WagnerAACC19.pdf

AACC 2019 -- Symmetric and asymmetric dimethylarginine (SDMA and ADMA) are metabolites of the post-translational modification of arginine residues in histones. SDMA is produced by all body tissues and is cleared almost exclusively by the kidneys, making it an attractive biomarker for the evaluation of renal function.

August 4, 2019

Kim-KincaidAACC19.pdf

AACC 2019 -- Hepatotoxicity is an ongoing focus for drug development. Drug-induced liver injury (DILI) figures prominently in the termination of candidates for new drug applications to the FDA and other regulatory authorities.

August 4, 2019

NarlaAACC19-Troponin.pdf

AACC 2019 -- The requirements from IFCC (International Federation of Clinical Chemistry) to qualify a cardiac Troponin assay to be qualified as a high sensitive assay are that the, Assay must have analytical imprecision of 10% at the 99th percentile, Assay must be able to measure cTn above the LOD in >50% of the patients and the 99th percentile should b

August 9, 2019

Conquering Your Clinical Data Management Challenges

How can you free your teams to focus on innovation and clinical development? Labcorp FSPx can help, find out how.

September 3, 2019

PyMT - A transplantable Murine model of breast cancer

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September 9, 2019

LedvinaAPA19.pdf

APA 2019 -- This poster presents a general liquid microsampling methodology where a small (< 50 �L) whole blood sample is collected, followed by plasma harvest and volumetric dilution. A pilot study is also presented, comparing this technique to conventional collection (jugular bleed) in rats, and finding the two methods yield similar PK curves.