CORESTA Congress 2024 -- The use of 3D in vitro airway tissue models that closely mimic the physiological architecture and microenvironment of the human respiratory system is critically important when studying aerosol exposure. Presence of a pseudostratified mucociliary epithelium and mucus secreting goblet cells help to provide a more accurate representation of the deposition, dissolution and clearance patterns of inhaled aerosols during human exposure. The objective of this study was to validate the Vitrocell® 48 2.0+ 24-well module by quantifying delivered dose across a range of dilutions from both reference cigarettes and electronically heated tobacco products (eHTPs). The study findings revealed low variation within dilution airflow, overall good dose resolution and supports the use of this module in relevant toxicological investigations and risk assessments.

• Download