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MYOMARKER ® PROFILE
Myositis
Comprehensive, Innovative Profile and Tests to Help Identify Inflammatory Myopathies
Inflammatory Myopathies
Idiopathic inflammatory myopathies (IIM), commonly known as myositis, are rare conditions that can affect multiple organs apart from muscle and often lead to a severe impairment of the quality of life.
Diagnosis and treatment are often challenging and usually require testing of auto-antibodies.1
Labcorp offers a myositis profile performed using RIPA and EIA methodologies. MyoMarker® 3 Plus profile includes both myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA), as well as anti-SAE-1 antibody.
Clinical Utility
IIMs are a heterogeneous group of disorders characterized by muscle weakness, resulting from chronic muscle inflammation of unknown cause. Patients with IIM have a variety of autoantibodies with various clinical associations that fall into two main groups:
Myositis-specific autoantibodies (MSA)*
MSA are highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, and necrotizing myositis
Myositis-associated autoantibodies (MAA)*
MAA appears in myositis overlap syndromes and in other connective tissue diseases, which correlate with certain clinical and/or pathophysiological conditions
Other Myositis-specific autoantibodies (MSA)*
- Anti-HMGCR Ab
- Anti-cN-1A Ab (NT5c1A) IBM (RDL)
*Individual components can be ordered separately
Myositis Profile and Related Testing
MyoMarker® 3 Plus Profile includes both myositis-specific antibodies and myositis-associated antibodies, as well as anti-SAE-1 antibody.
MSA are found only in patients with myositis and have been shown to be highly specific for patients with polymyositis (PM), dermatomyositis (DM), anti-synthetase syndrome, necrotizing myositis and overlap syndromes. MAA can be found in patients with overlap syndromes such as polymyositis/scleroderma and may also be found in non-overlap syndromes.
Labcorp offers MyoMarker® 3 Plus Profile performed using RIPA and EIA methodologies.
RIPA gel radiography utilizes immunoprecipitation, gel electrophoresis and autoradiography to identify radioisotope-labeled proteins from human erythroleukemic cell extracts that are targeted by autoantibodies in patient serum. RIPA gel radiography is a powerful, reliable technology that has been used and refined for more than 30 years to identify many PM/DM autoantibodies with high sensitivity, specificity and reproducibility. It is the original methodology of studies that defined various myositis-specific and myositis-associated antibodies.2
| Other Myositis-Specific Antibodies |
|---|
|
Anti-HMGCR Ab (RDL) Anti-cN-1A Ab (NT5c1A) IBM (RDL) |
| Number | Name |
|---|---|
| 520085 | MyoMarker® 3 Plus Profile (RDL) |
| Myositis-Specific Antibodies | Myositis-Associated Antibodies |
|---|---|
|
Anti-Jo-1 Anti-PL-7 Anti-PL-12 Anti-EJ Anti-OJ Anti-SRP Anti-Mi-2 Anti-TIF-1gamma (part of P155/140 Kd) Anti-MDA-5-Ab (CADM-140) Anti-NXP-2 (P140) Anti-SAE-1 |
Anti-PM/Scl-100 Anti-SS-A 52kD Anti-Ku Anti-U1 RNP Anti-U2 RNP Anti-U3 RNP (Fibrillarin) |
Labcorp offers legacy RDL MyoMarker® 3 Plus Profile to help identify inflammatory myopathies
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